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目的探讨纳络酮作为一种特异性阿片受体拮抗剂对苯二氮类中毒致昏迷患者的疗效。方法将我院急诊科2004年2月至2007年5月收治的160例苯二氮类中毒致昏迷者随机分为2组,治疗组80例,在常规治疗基础上使用纳洛酮;对照组80例,常规行洗胃、吸氧、利尿、解毒及对症治疗。结果苯二氮类中毒致昏迷者纳洛酮组与对照组总有效率和病死率经统计学处理差异有显著性(P<0.01)。结论纳洛酮虽非特效解毒药但其应用可使苯二氮类中毒患者清醒时间明显提前,不良反应小,并且清醒后出现嗜睡、头昏乏力、纳差等症状较轻,是一种安全、有效、值得推广应用的治疗药物。
Objective To investigate the efficacy of naloxone as a specific opioid receptor antagonist in patients with coma caused by benzodiazepine poisoning. Methods One hundred and sixty patients with narcolepsy induced by benzodiazepine poisoning in our emergency department from February 2004 to May 2007 were randomly divided into two groups, 80 in the treatment group and naloxone on the basis of routine treatment. Group 80 cases, routine gastric lavage, oxygen, diuretic, detoxification and symptomatic treatment. Results The total effective rate and case fatality rate of naloxone group were significantly lower than those of the control group (P <0.01). Conclusion Although naloxone is not a special antidote, its application can make the awake time of benzodiazepine poisoning significantly earlier with less adverse reactions, and it is a kind of mild symptom such as drowsiness, dizziness and weakness, Safe and effective, it is worth to promote the use of therapeutic drugs.