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目的通过事件相关电位(ERP)观察非痴呆帕金森病(PD)患者识别、区分熟悉和不熟悉人名的认知能力有无损害,以及ERP变化与认知功能损害程度的相关性。方法采用EMS32导脑电地形图机及其处理系统,以熟悉和不熟悉的人名作为诱发ERP的任务,观察32例PD病患者事件相关电位P300波群的变化。结果 (1)PD患者组熟悉人名和不熟悉人名诱发的P3波幅之差较对照组明显缩小(P<0.05);(2)PD患者无论熟悉人名与不熟悉人名诱发的N2、P3潜伏期与MMSE评分呈显著负相关性(P<0.01),MMSE评分24分～26分PD患者组与正常对照相比,N2、P3潜伏期显著延长(熟悉:P<0.01;P<0.01;不熟悉:P<0.01;P<0.01),而P3波幅与正常对照之间则无显著差异(P>0.05)。结论非痴呆PD患者识别熟悉人名的认知能力下降,事件相关电位潜伏期延长可反映PD患者轻度认知功能损害,并与其损害程度相关。
Objective To observe the identification of patients with dementia without Parkinson’s disease (PD) through event-related potentials (ERP), and to determine whether there is any impairment of cognitive ability between familiar and unfamiliar names, and the correlation between ERP changes and cognitive impairment. Methods The EMS32-guided electroencephalogram topography machine and its processing system were used. The familiar and unfamiliar names were used as the task of inducing ERP. The changes of the event-related potential P300 wave group in 32 PD patients were observed. Results (1) The difference of P3 amplitude induced by familiar names and unfamiliar names in PD patients was significantly smaller than that in control subjects (P <0.05). (2) The N2, P3 latency and MMSE (P <0.01). MMSE score of 24 to 26 minutes in patients with PD compared with the normal control, N2, P3 latency was significantly longer (familiar with: P <0.01; P <0.01; not familiar with: P < 0.01; P <0.01), but there was no significant difference between P3 amplitude and normal control (P> 0.05). Conclusion The cognitive ability of nondementia PD patients to recognize familiar names is decreased. The prolongation of event-related potentials may reflect the mild cognitive impairment in patients with PD, and is related to the degree of impairment.