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1957年英国开始普遍开展百日咳的自动免疫(使用百白破三联制剂,下同).曾进行过大规模的现场试验,并证明了一些百日咳菌苗的保护效果可达80%~(1).1957~1962年,百日咳的报告发病数显著下降,当时普遍认为这是广泛进行预防接种的结果.1963年百日咳病例又复增加,受种儿童仍患百日咳的情况也屡有报道.于1966年开始重新对菌苗效果进行了18个月的大规模现场调查~(2、3).调查了英国33个地区,共3564个家庭.主要是观察按当时英国规定的
In 1957, the United States started the universal immunization of whooping cough (the use of diphtheria trilobetal, the same below.) Have conducted large-scale field trials and proved that some of the pertussis vaccine protection effect of up to 80% ~ (1). The incidence of whooping cough reported a significant drop in incidence between 1957 and 1962 when it was generally believed that this was the result of widespread immunization. The cases of whooping cough increased again in 1963 and the subject was still reported to have had pertussis. The results of a large-scale field survey of 18 months were repeated for vaccine efficacy.2,3 The 3564 families in 33 districts in the United Kingdom were surveyed,