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目的探讨鲍氏不动杆菌医院感染分布特点及耐药性。方法常规细菌培养方法,细菌鉴定采用法国生物梅里埃公司VITEK32全自动细菌鉴定仪,药敏试验采用琼脂纸片扩散法。结果鲍氏不动杆菌最常出现在痰标本中,占78.64%,其次是分泌物(9.62%)和尿液(6.81%),鲍氏不动杆菌感染以重症监护病房最多(29.58%),其次是呼吸科病房(21.36%);该菌耐药现象严重,耐药率较低的抗菌药物是含酶抑制剂如头孢哌酮/舒巴坦(22.14%)、碳青酶烯类药物如美罗培南(32.95%)、亚胺培南(33.04%)等。结论鲍氏不动杆菌在临床的多药耐药呈上升趋势,因此对鲍氏不动杆菌应进行规范的连续的耐药监测,及早发现耐药菌株,调整治疗方案。
Objective To investigate the distribution and drug resistance of Acinetobacter baumannii nosocomial infection. Methods The conventional bacterial culture method and bacterial identification were performed by VITEK32 automatic biomonitoring system of French bioMérieux. The drug susceptibility test was performed by agar diffusion method. Results Acinetobacter baumannii was most commonly found in sputum samples, accounting for 78.64%, followed by secretions (9.62%) and urine (6.81%), and Acinetobacter baumannii infection was the highest in ICU (29.58%), Followed by the respiratory ward (21.36%). The antibiotic resistance of this bacterium was very serious. The antibacterials with low resistance rate were antibiotics with enzyme inhibitors such as cefoperazone / sulbactam (22.14%), carbapenems such as Meropenem (32.95%), imipenem (33.04%) and so on. Conclusion Acinetobacter baumannii in clinical multidrug resistance is on the rise, therefore Acinetobacter baumannii should be standardized continuous monitoring of drug resistance, early detection of drug-resistant strains, adjust the treatment.