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IGF-1是生长激素促进生长作用的一种介质。许多研究推测,IGF-1可能是一种生长促进因子,在增殖性糖尿病性视网膜病(PDR)的发病中起某种作用。但有些研究结果相反,故目前仍是个有争议的问题。 作者分析682例成人糖尿病患者的测定结果,其IGF-1从35到670μg/L,平均值227±108μg/L,明显低于非糖尿病组(315±147μg/L)。Spe-arman进行分项相关分析提示,IGF-1水平与年龄(r=-0.51,P<0.0001),病程(r=-0.36,P<0.0001)和糖化血红蛋白(r=-0.09,
IGF-1 is a mediator of growth hormone growth. Many studies speculate that IGF-1 may be a growth-promoting factor that plays a role in the pathogenesis of proliferative diabetic retinopathy (PDR). However, some studies have the opposite result, so it is still a controversial issue at present. The authors analyzed 682 adults with diabetes mellitus, whose IGF-1 levels ranged from 35 to 670 μg / L with an average of 227 ± 108 μg / L, significantly lower than those in non-diabetic patients (315 ± 147 μg / L). Spearman correlation analysis showed that IGF-1 levels were positively correlated with age (r = -0.51, P <0.0001), duration of disease (r = -0.36, P <0.0001) and HbA1c (r =