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扎那米韦(Zanamivir)是甲、乙型流感病毒神经氨酸酶的强力选择性抑制剂,已证实治疗急性期流感有效,并且用每日一次的扎那米韦作季节性预防也有效。本文旨在评价该药对流感患者的家庭接触者接触后的预防作用、流感的疗效及家庭接触者与流感患者同时使用扎那米韦后,耐药毒株产生的可能性。
Zanamivir is a potent and selective inhibitor of influenza A and B neuraminidase and has been shown to be effective in the treatment of influenza in the acute phase and also as a seasonal prophylaxis with daily zanamivir. This article aims to evaluate the prophylactic effect of this medicine on contact with family contacts of influenza patients, the efficacy of influenza and the possibility of emergence of drug-resistant strains after concurrent use of zanamivir between family contacts and flu patients.