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目的探讨急性百草枯中毒患者血浆脑钠肽(BNP)与预后的关系。方法急性百草枯中毒患者67例,以住院死亡为观察终点分为死亡组和存活组。采用免疫放射分析法测定中毒后24h内患者血浆BNP含量并进行统计分析。结果血浆BNP增高的46例患者,病死率80.43%。死亡组血浆BNP显著高于存活组。结论血浆BNP在百草枯中毒24h内明显增高的患者病情重,病死率高,预后差。早期动态监测血浆BNP能客观评估病情程度及预后。
Objective To investigate the relationship between plasma brain natriuretic peptide (BNP) and prognosis in patients with acute paraquat poisoning. Methods Sixty-seven patients with acute paraquat poisoning were divided into death group and survival group with hospitalized death as the end point. Plasma BNP levels in patients within 24 hours after poisoning were determined by immuno-radioactive assay and statistical analysis was performed. Results 46 cases of plasma BNP increased mortality was 80.43%. Plasma BNP was significantly higher in the death group than in the surviving group. Conclusion Plasma BNP in paraquat poisoning 24h significantly increased in patients with severe illness, high mortality and poor prognosis. Early dynamic monitoring of plasma BNP can objectively assess the severity and prognosis.