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河北省赞皇县是胃癌高发区,胃癌年均死亡率为59/10万。经癌瘤病因流行病学调查,发现该县不同地理环境的行政乡胃癌死亡率相差悬殊。例如,西南部胃癌高发区的楼底乡为深山区(胃癌死亡率126.95/10万),当地居民主粮为玉米。玉米收获后不脱粒,堆放于房顶晒干,经风吹雨淋,常有霉变现象。研磨好的玉米面贮于阴暗、通风差的缸内,更有助于霉菌生长。东北部胃癌相对低发区的张楞乡为丘陵地区(胃癌死亡率为28.11/10万),居民主粮品种较多,玉米亦为主粮之一,但霉变现象较轻。为探讨真菌毒素和胃癌发生的关系,本实验用HPLC法对胃癌高发区和相对低发区居民主粮玉米而进行了真菌毒素检测。
Zanhuang County, Hebei Province, is a high incidence of gastric cancer, the annual average mortality rate of gastric cancer 59/10 million. Epidemiological survey of the etiology of cancer found that the county’s geographical environment of the administrative area of stomach cancer mortality difference. For example, in the southwest of the high incidence of gastric cancer floor area is deep mountainous area (gastric cancer death rate 126.95 / 100,000), local residents staple food is corn. Corn is not threshed after harvest, stacked on the roof dry, the wind and rain, often mildew phenomenon. Grind the cornmeal in dark, poorly ventilated tanks, but also help mold growth. The relatively low incidence of gastric cancer in the northeast of Zhang Leng for the hilly areas (gastric cancer mortality was 28.11 / 100000), more residents of staple food varieties, corn is also one of the staple food, but less mildew phenomenon. In order to explore the relationship between mycotoxins and gastric cancer, this experiment using HPLC method for high incidence of gastric cancer and relatively low incidence of food staple corn for mycotoxin testing.