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目的观察美沙拉嗪口服联合中药灌肠治疗溃疡性结肠炎的临床疗效。方法 65例患者随机分为治疗组35例,用美沙拉嗪口服联合中药保留灌肠,对照组30例用SASP口服及保留灌肠,观察两组临床症状、结肠黏膜的改善情况及不良反应。结果治疗组和对照组的总有效率分别为94.3%和73.3%,两组临床疗效比较有显著性差异(P<0.05),治疗组症状及结肠黏膜的改善情况优于对照组(P<0.05),治疗组与对照组的不良反应比较有高度显著性差异(P<0.01)。结论美沙拉嗪口服联合中药保留灌肠治疗溃疡性结肠炎安全有效。
Objective To observe the clinical efficacy of mesalazine combined with traditional Chinese medicine enema in the treatment of ulcerative colitis. Methods A total of 65 patients were randomly divided into treatment group (n = 35), mesalazine oral administration combined with traditional Chinese medicine retention enema, and control group (n = 30) with SASP orally and retention enema. The clinical symptoms, colonic mucosa improvement and adverse reactions were observed in both groups. Results The total effective rates of the treatment group and the control group were 94.3% and 73.3%, respectively. There was significant difference between the two groups in clinical curative effect (P <0.05), and the improvement of symptoms and colonic mucosa in the treatment group was better than that in the control group (P <0.05 ), There was a highly significant difference in adverse reactions between the treatment group and the control group (P <0.01). Conclusion Mesalazine combined with traditional Chinese medicine retention enema for the treatment of ulcerative colitis is safe and effective.