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用HCG－DT免疫家兔。抽提肝脾组织中的i-RNA注射到正常免后数日内在血清中检测到抗体。抗体能中和HCG的活性。这种效应与剂量大小和注射途径有关。小剂量抗原刺激可以迅速提高血清中抗体水平。抗体水平可维持两个月以上（未继续监测）。此i－RNA同样可传递给第二受体免获得免疫信息。
Rabbits were immunized with HCG-DT. Antibodies were detected in serum within days of extraction of i-RNA from liver and spleen tissues to normal within a few days. Antibodies neutralize HCG activity. This effect is related to the size of the dose and the route of injection. Small doses of antigen stimulation can rapidly increase serum antibody levels. Antibody levels can be maintained for more than two months (no further monitoring). This i-RNA is also delivered to the second receptor free of immune messages.