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This paper is devoted to the homogenization of a semilinear parabolic equation with rapidly oscillating coefficients in a domain periodically perforated by e-periodic holes of size ε. A Neumann condition is prescribed on the boundary of the holes.The presence of the holes does not allow to prove a compactness of the solutions in L2. To overcome this difficulty, the authors introduce a suitable auxiliary linear problem to which a corrector result is applied. Then, the asymptotic behaviour of the semilinear problem as e → 0 is described, and the limit equation is given.