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Objective:To study curcumins growth inhibitory effects and morphology changes on sarcoma grafts of S180 mouse,with further inquiry into the possible mechanisms.Methods:Thirty S180 mouse were randomly assigned into 3 groups:saline group (blank control group),Cytoxan group (positive control group)and curcumin group.The tumor inhibitory rates,the index of thymus and spleen,the growth of tumor and the change of pathology-morph,the index of apoptosis cells and morphology changes of apoptosis cells in the different groups were observed.Results:(1) Tumors inhibitory rate in curcumin group and cytoxan group was 68.32% and 70.43%,respectively.Compared to blank control group,the 2 groups had significant elevated tumor inhibitory rate(P＜0.01).(2) Thymus index of curcumin group did not have significant decrease compared to blank control group (P＞0.05).(3)Under electroscope,curcumin group and positive control group had significant decrease in terms of growth of tumor,degree of infiltration of tumor,the number of nucleus fission,and blood vessels number compared to saline group (P＜0.05).However,the degree of cell necrosis,the number of splenic segments and macrophage are increased significantly compared to negative group.(4) Accumulative score of apoptosis cell in curcumin group was significantly higher than other two groups(P＜0.05).Conclusion:Internal organ study and cell morphology observation show curcumin can effectively inhibit the growth and cause the death of sarcoma graft of S180 mouse without interference with thymus.