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目的探讨促性腺激素释放激素激动剂(GnRH-α)辅助腔镜手术治疗卵巢子宫内膜异位囊肿的临床疗效。方法选取2013年1月至2014年6月收治的70例卵巢子宫内膜异位囊肿患者,随机分为两组,每组35例。观察组采用腹腔镜手术联合GnRH拮抗剂治疗,对照组采取常规腹腔镜手术联合孕三烯酮治疗。治疗结束后,随访1年,观察两组治疗效果、妊娠受孕情况、复发率及安全性。结果观察组总有效率与复发率分别为85.71%和5.71%,与对照组比较,差异无统计学意义(P>0.05)。观察组月经量与月经周期分别为(45.56±3.22)ml和(35.34±5.51)d,与对照组比较,差异具有统计学意义(P<0.05)。观察组不良反应发生率为17.14%,显著低于对照组的40%,差异具有统计学意义(P<0.05)。结论 GnRH激动剂辅助腹腔镜手术治疗卵巢子宫内膜异位囊肿疗效显著,复发率和术后不良反应发生率低,且可改善月经状态,提高妊娠成功率。
Objective To investigate the clinical efficacy of gonadotropin-releasing hormone agonist (GnRH-α) assisted endoscopic surgery for ovarian endometriosis. Methods Seventy patients with ovarian endometriosis admitted from January 2013 to June 2014 were randomly divided into two groups (n = 35 in each group). The observation group was treated with laparoscopic surgery combined with GnRH antagonist, while the control group was treated with conventional laparoscopic surgery combined with gestrinone. After treatment, follow-up of 1 year, the two groups were observed treatment effect, pregnancy conception, recurrence rate and safety. Results The total effective rate and recurrence rate in the observation group were 85.71% and 5.71%, respectively. There was no significant difference between the two groups (P> 0.05). The menstrual flow and menstrual cycle in the observation group were (45.56 ± 3.22) ml and (35.34 ± 5.51) d, respectively, which were significantly different from those in the control group (P <0.05). The incidence of adverse reactions in the observation group was 17.14%, which was significantly lower than that in the control group (40%), the difference was statistically significant (P <0.05). Conclusion GnRH agonist assisted laparoscopic treatment of ovarian endometriosis cysts significant effect, the recurrence rate and postoperative adverse reaction rate is low, and can improve the menstrual status and improve the success rate of pregnancy.