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目的：评价图像引导调强放疗（IGRT）联合周剂量紫杉醇持续静脉滴注同期放化疗不能手术食管癌的疗效及毒副反应。方法2014-2015年50例不能手术的食管鳞癌入组，非手术临床分期为Ⅱ-Ⅲ期。行CT模拟定位，图像引导调强放疗（IGRT），总剂量为63Gy，放疗第一天即配合化疗（具体方案：紫杉醇45mg/m2 CIV 16h d1 qW×6）。结果近期总有效率为98%，1、2年随访的病人数分别为46、34例，1、2年的局部控制率分别为92%、78%，1、2年的总生存率分别为92%、68%，急性毒副反应的主要表现是骨髓抑制，以白细胞减少、中性粒细胞减少为主，非血液学毒性反应轻微。结论 IGRT联合周剂量紫杉醇持续静脉滴注同期放化疗不能手术食管癌的局部控制率高，在应用集落刺激因子后骨髓抑制可以耐受。“,”Objective To evaluate the efficacy and toxicity of image guided radiation therapy (IGRT)combined with weekly continuous intravenous drip paclitaxel in concurrent chemoradiotherapy of unresectable esophageal carcinoma. Methods Between 2014 and 2015,50 patients with histologically diagnosed esophageal squamous cell carcinoma in nonsurgical clinical stage II to Ⅲwere enrolled in this study. All patients were confirmed as unresectable and treated by image guided radiation therapy (IGRT) of 63Gy concurrently with chemotherapy on first day. (Concreteness:paclitaxel 45mg/m 2 continuous intravenous drip in 16 hours on day 1,once weekly for 6 times). Results The overall response (including complete response and partial response) rate was 98%. The 1 and 2 year follow-up visit patients were 46 and 34. The 1 and 2 year local control rates in group were 92%and 78%. The 1 and 2 year overall survival rates were 92% and 68%. The major acute toxicity was hematologic toxicity,especially leukopenia and neutropenia. While severe nonhemotologic toxicity was infrequent. Conclusion Image guided radiation therapy (IGRT) combined with weekly continuous intravenous drip paclitaxel in concurrent chemoradiotherapy has high local control in unresectable esophageal carcinoma,while tolerable hematological toxicity with colony stimulating factors using.