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目的 探讨辨证分型治疗视网膜色素变性 (retinitispigmentosa ,RP)与患者血管内皮 -血小板功能改变的关系。方法 接受辨证分型治疗的视网膜色素变性患者中包括 44例脾肾阳虚型和 2 1例肝肾阴虚型患者。对患者的血浆血栓素B2 、 6 -酮 -前列腺素F1α及自由基进行了检测 ,并与 33例正常人对照分析。结果 两组RP患者中TXB2 、T/K升高 ,6 -K -PGF1α及SOD降低。脾肾阳虚组患者TXB2 、T/K较肝肾阴虚组升高更为明显 ;患者的SOD与TXB2 、 6-K -PGF1α及T/K的相关分析表明他们之间差异无显著性意义。结论 视网膜色素变性患者的辨证分型与血管内皮 -血小板功能改变之间存在一定的关系。血管内皮 -血小板功能改变的检测结果可作为对视网膜色素变性患者进行辨证分型的客观指标之一。
Objective To investigate the relationship between syndrome differentiation and treatment of retinitis pigmentosa (RP) and vascular endothelial function in patients with platelet function. Methods Patients with retinitis pigmentosa undergoing syndrome differentiation and treatment included 44 cases of spleen and kidney yang deficiency and 21 cases of liver and kidney yin deficiency. Thromboxane B2, 6 - keto - prostaglandin F1α and free radicals in plasma were detected and compared with 33 normal controls. Results The levels of TXB2, T / K and the decrease of 6-K-PGF1α and SOD in the two groups of RP patients were lower than those in the control group. TXB2 and T / K in spleen and kidney yang group were more obvious than those in liver and kidney yin deficiency group. The correlation analysis of SOD, TXB2, 6-K-PGF1α and T / K showed no significant difference between them . Conclusion There is a certain relationship between the syndrome differentiation of patients with retinitis pigmentosa and the change of vascular endothelium-platelet function. Vascular endothelium - platelet function test results can be used as a differential diagnosis of retinitis pigmentosa patients objective indicators.