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在有典型的CML特点的患者中,发现Ph~1染色体就可对该患者做出诊断,这是比较清楚的。但问题是,如何把似乎类似于CML的某种骨髓细胞增生性疾病的患者和没有Ph~1染色体的患者加以恰当的分类。在不同的报导中,Ph~1-阴性的CML患者的比例变化在10～36％之间,其中的一些差异可能反映了诊断标准的不同。本文的目的是确定Ph~1-阴性的CML诊断标准、CML患者中Ph~1-阴性患者的百分比,研究在疾病的早期及演化时所出现的染
In patients with typical CML characteristics, it is clear that the Ph ~ 1 chromosome can be diagnosed in this patient. But the question is how to properly classify some patients with myeloproliferative disorders that appear to be similar to CML and those without Ph-1. In various reports, the proportion of Ph-1-negative CML varies between 10 and 36%, some of which may reflect differences in diagnostic criteria. The purpose of this paper is to determine the diagnostic criteria for Ph-1-negative CML, the percentage of Ph ~ 1-negative patients in CML, and the effects of the dye on early and evolving disease