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目的:观察糖肠宁对糖尿病肠病泄泻型大鼠胃肠激素的影响。方法:将80只大鼠随机分为5组,即正常对照组、模型对照组、西药治疗组和糖肠宁治疗高、低剂量组,脾肾两虚型腹泻糖尿病模型大鼠灌胃15天后,测定各组大鼠血清胃泌素(GAS)和生长抑素(SST)及空肠组织中P物质(SP)。结果:各治疗组较模型组血清GAS和空肠组织中SP减少(P<0.05);各治疗组较模型组血清SST增加(P<0.05)。结论:糖肠宁可以通过调节体内胃肠肽类激素含量治疗糖尿病肠病,且较西药思密达具有优势。
Objective: To observe the effects of Tangchangning on gastrointestinal hormones in diabetic diarrhea rats. Methods: Eighty rats were randomly divided into five groups: normal control group, model control group, western medicine treatment group and sausage injection treatment high and low dose group, spleen and kidney deficiency type diarrhea diabetic rats after 15 days The levels of serum gastrin (GAS), somatostatin (SST) and substance P (SP) in jejunum of rats in each group were determined. Results: Compared with model group, serum GAS and jejunum SP decreased in all treatment groups (P <0.05). The serum SST in each treatment group increased (P <0.05). Conclusion: Tangchangning can treat diabetic gut enteropathy by regulating the content of gastrointestinal peptide hormones in vivo, which is superior to that of western medicine.