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目的探讨阴道上皮内瘤变(VAIN)与宫颈上皮内瘤变(CIN)的相关性及其诊断和治疗。方法回顾性分析30例VAIN患者的临床表现、阴道脱落细胞学、人乳头状瘤病毒(HPV)感染以及治疗方法等资料。结果患者平均年龄44.9岁,VAINⅠ、VAINⅡ、VAINⅢ分别占53.3%(16/30)、33.3%(10/30)和13.3%(4/30);VAINⅢ在年龄≤40岁者和>40岁者中分别为10%(1/10)和20%(4/20);80.0%(24/30)患者有CIN病史,13.3%(4/30)有宫颈癌病史;CINⅠ、CINⅡ～Ⅲ和宫颈癌中分别有3/9、53.3%(8/15)和2/4发生VAINⅡ～Ⅲ;96.6%(28/29)患者液基细胞学检查结果异常。86.7%(26/30)患者病变位于阴道上1/3。结论 VAIN临床特点与CIN相似,CIN诊断和治疗原则也可适用于VAIN。
Objective To investigate the relationship between vaginal intraepithelial neoplasia (VAIN) and cervical intraepithelial neoplasia (CIN) and its diagnosis and treatment. Methods Retrospective analysis of 30 cases of VAIN clinical manifestations, vaginal cytology, human papillomavirus (HPV) infection and treatment methods and other data. Results The average age of patients was 44.9 years. The rates of VAINⅠ, VAINⅡ and VAINⅢ were 53.3% (16/30), 33.3% (10/30) and 13.3% (4/30) respectively. The patients with VAINⅢ were less than 40 years old and 40 years old (10% (1/10) and 20% (4/20 respectively; 80.0% (24/30) had CIN history, 13.3% (4/30) had cervical cancer history; CINⅠ, CINⅡⅢ and cervix There were 3/9, 53.3% (8/15) and 2/4 VAINⅡ ~ Ⅲ in cancerous tissues respectively; 96.6% (28/29) patients had abnormal liquid-based cytology. 86.7% (26/30) patients located in the vagina on the pathological 1 / Conclusions The clinical features of VAIN are similar to those of CIN. The diagnostic and therapeutic principles of CIN are also applicable to VAIN.