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α-CAM是一新的阿片受点不可逆激动剂,在离体组织(GPI,MVD,RVD和RbVD)及大鼠脑P_2膜制备上均表现不可逆作用。对小鼠镇痛(icv)ED_(50)为0.12 nmol/鼠,镇痛作用可持续2～3 d,是迄今所知镇痛时间最长的化合物。一次注射(icv)即可使小鼠成瘾,可作为研究成瘾机理的工具药。
α-CAM is a new opioid irreversible agonist. It shows an irreversible effect on the preparation of P_2 membrane of rat brain in vitro (GPI, MVD, RVD and RbVD). The analgesic effect of icv (ED 50) was 0.12 nmol / mouse in mice and the analgesic effect lasted for 2 ~ 3 days. It is the compound known to have the longest analgesic effect to date. One injection (icv) can addicted mice, can be used as a tool to study the mechanism of addiction medicine.