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采用噻唑盐 (MTT)比色方法研究在紫外线辐射损伤条件下扇贝多肽对免疫细胞的保护作用 ,并探讨扇贝多肽对胸腺细胞和脾细胞活性的影响。结果表明 ,扇贝多肽具有抗紫外线氧化损伤的作用 ,可减轻或抑制紫外线对胸腺细胞和脾细胞的氧化损伤 ,并且呈剂量依赖性。扇贝多肽在 0 .5%— 1 0 .0 %的浓度范围内 ,其抗氧化能力随浓度的增高而增强 ;在正常条件下可显著增强免疫细胞的活性 ,并且可拮抗雌激素对免疫细胞的抑制作用。提示扇贝多肽不仅具有抗氧化损伤作用 ,而且具有免疫增强作用。
The thiazole salt (MTT) colorimetric method was used to study the protective effect of scallop peptides on immune cells under ultraviolet radiation damage, and the effect of scallop peptides on the activity of thymocytes and spleen cells was investigated. The results showed that scallop peptides have anti-ultraviolet oxidative damage, which can reduce or inhibit the oxidative damage of thymocytes and spleen cells induced by ultraviolet radiation in a dose-dependent manner. In the concentration range of 0.5%-10.0%, the scallop peptides increased their antioxidant capacity with increasing concentrations; under normal conditions, they significantly enhanced the activity of immune cells and could antagonize the effects of estrogen on immune cells. Inhibition. It is suggested that scallop peptide not only has antioxidative damage but also has immunopotentiating effect.