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[目的]为更好地利用马蹄加工皮渣中的资源，优化马蹄皮渣中总黄酮的微波提取工艺，得到得率较高的黄酮类化合物。[方法]采用 Box-Behnken中心组合响应面法优化马蹄粉加工皮渣中总黄酮的微波提取工艺，建立了不同影响因素与马蹄总黄酮得率之间的函数关系。[结果]确定最佳提取工艺条件为：乙醇浓度55.4%，料液比1：30 g/ml，微波功率320 W，微波3 min，在此条件下重复提取2次，理论得率为2.376%，经过验证得到总黄酮得率为2.365%，实测值与理论预测值之间的相对误差为0.461%。[结论]优化得到的提取工艺可靠，可为马蹄加工废弃物的综合高效利用提供参考依据。“,”Objective] ln order to take ful advantage of processing by-product of wa-ter chestnut, the microwave extraction method of flavonoids from water chestnut skin dregs was optimized. The extracted flavonoids had a relatively high yield. [Method] The Box-Behnken design-based response surface method was adopted to optimize the microwave extraction of flavonoids from water chestnut skin dregs, a by-product of water chestnut starch. The mathematical relationships between various influencing factors and flavonoids yield were established. [Result] The optimum ex-traction conditions of flavonoids from water chestnut skin dregs were as fol ows:ethanol concentration of 55.4%, solid/liquid ratio of 1:30 g/ml, microwave power of 320 W, microwave time of 3 min and microwave time of 2 times. Under the opti-mum extraction conditions, the theoretical flavonoids yield was 2.376%. However, the actual flavonoids yield under the optimum extraction conditions was 2.365%. The relative error between actual values and theoretical y predicted values was 0.461%. [Conclusion] The results showed the optimized extraction method is reliable, and it can provide a reference for the comprehensive and highly efficient utilization of wa-ter chestnut processing wastes.