论文部分内容阅读
目的观察鼻敏感方对变应性鼻炎模型大鼠的影响,探讨鼻敏感方治疗变应性鼻炎可能的作用机制。方法取SD大鼠48只,随机分为空白对照组,模型组,鼻敏感方高、中、低剂量组(20,10,5 g·kg-1·d-1),氯雷他定组(1.67 mg·kg-1·d-1),共6组,每组8只。以卵清蛋白为致敏原建立大鼠变应性鼻炎模型,观察各组大鼠行为表现,测定白细胞介素-4(IL-4)和干扰素-γ(IFN-γ)细胞因子水平,观察鼻黏膜病理形态变化。结果与模型组比较,鼻敏感方各剂量组及氯雷他定组鼻痒、喷嚏、清涕等症状明显减轻(P<0.01),鼻黏膜炎症程度减轻(P<0.05),血清IFN-γ水平升高,IL-4水平降低(P<0.01)。结论鼻敏感方可显著改善大鼠鼻部症状,减轻鼻黏膜炎症程度,影响IL-4、IFN-γ水平,对AR病理模型具有较好的疗效。
Objective To observe the effect of nasal sensitive prescription on allergic rhinitis in rats, and to explore the possible mechanism of nasal sensitive prescription in treating allergic rhinitis. Methods Forty-eight SD rats were randomly divided into control group, model group, high, middle and low dose rhinosinusitis group (20, 10, 5 g · kg -1 · d -1), loratadine group (1.67 mg · kg-1 · d-1), a total of 6 groups of 8. The rat model of allergic rhinitis was established with ovalbumin as allergen. The behavior of rats in each group was observed. The levels of interleukin-4 (IL-4) and interferon-γ (IFN-γ) Observe nasal mucosa pathological changes. Results Compared with the model group, the symptoms such as nasal itching, sneezing, clearness of the nose and nasal mucosa were relieved significantly (P <0.01), the inflammatory degree of nasal mucosa was relieved (P <0.05) Elevated levels of IL-4 decreased (P <0.01). Conclusion Nasal sensitive prescription can significantly improve the nasal symptoms, reduce the degree of inflammation of the nasal mucosa, affect the levels of IL-4 and IFN-γ, and have a good curative effect on AR pathological models.