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本研究试用短小棒状杆菌菌苗对11例慢性支气管炎患者进行治疗和免疫学观察,治疗期间每周记录病情并处理一次,一个治疗程(12周)后,91%患者获疗效.治疗前和疗程结束时,作了淋转试验(~3H-TdR摄入法),治疗后10例的淋巴细胞摄入~3H-TdR量比治疗前有不同程度的升高(P<0.01);还作了白细胞移动抑制试验,所有11例的白细胞移动指数均较治疗前低(P<0.01),其中10例降低明显.这些结果提示,短小棒状杆菌菌苗确能提高慢性支气管炎患者的T细胞免疫功能,从而发挥其治疗作用.
In this study, 11 patients with chronic bronchitis were treated and immunologically observed during the trial, and the disease was recorded and treated once a week during treatment, and 91% of patients were treated after one course of treatment (12 weeks) At the end of the course of treatment, lymph node metastasis (~ 3H-TdR ingestion) was observed. The amount of ~ 3H-TdR uptake by lymphocytes in 10 patients after treatment was significantly higher than that before treatment (P <0.01) The leukocyte mobilization inhibition test showed that the leukocyte migration index of all 11 patients was lower than that before treatment (P <0.01), and 10 of them were significantly lower than those before treatment. These results suggest that the Corynebacterium parvum vaccine can indeed enhance the T cell immunity in patients with chronic bronchitis Function, to play its therapeutic role.