论文部分内容阅读
目的探讨NOB1 mRNA(nin one binding protein)在食管鳞癌(esophageal squamous cell carcinoma,ESCC)患者组织中的表达及其与临床病理参数之间的关系。方法运用RT-PCR方法检测19例ESCC患者癌组织及对应的癌旁组织中NOB1mRNA的表达情况,分析NOB1mRNA表达与临床病理参数的关系。结果 19例ESCC患者癌组织及相应癌旁组织中,均检测到NOB1基因mRNA的表达。NOB1mRNA在ESCC组织(1.2133±0.14)中的表达明显高于癌旁食管组织(0.7142±0.11)中的表达,差异有统计学意义(<0.05)。并且NOB1mRNA在ESCC组织中的表达与年龄、性别、侵犯深度、淋巴转移、分化程度及临床分期无明显相关性,组间比较差异无统计学意义(>0.05)。结论 NOB1mRNA在ESCC组织中高表达,可能与ESCC的发生发展相关。
Objective To investigate the expression of NOB1 mRNA in tissues of patients with esophageal squamous cell carcinoma (ESCC) and its relationship with clinicopathological parameters. Methods RT-PCR was used to detect the expression of NOB1 mRNA in 19 cases of ESCC and corresponding paracancerous tissues. The relationship between NOB1 mRNA expression and clinical pathological parameters was analyzed. Results The mRNA expression of NOB1 gene was detected in all the 19 ESCC patients and their corresponding paracancerous tissues. The expression of NOB1 mRNA in ESCC tissue (1.2133 ± 0.14) was significantly higher than that in adjacent non-cancerous esophageal tissue (0.7142 ± 0.11), the difference was statistically significant (<0.05). The expression of NOB1 mRNA in ESCC tissues had no significant correlation with age, sex, invasion depth, lymph node metastasis, differentiation degree and clinical stage. There was no significant difference between the two groups (> 0.05). Conclusion The high expression of NOB1 mRNA in ESCC tissues may be related to the occurrence and development of ESCC.