Controlling intracellular Ca~(2+) spiral waves by the local agonist in the cell membrane

• 作 者: 仇康 唐军 马军 罗继明
• 机 构: Department of Mathematics and Physics,Xuzhou Medical College,College of Science,China University of
• 出 处: Chinese Physics B
• 发表日期: 2010年03期
• 关键词: intracellular agonist stimulation suppress enough spatially rotating messenger m

A modified spatially extended Tang-Othmer Ca2+ model is used to study intracellular Ca2+ spiral waves numerically.It is found that,as a local stimulation,the local agonist-binding on the cell membrane,which enhances the local concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP 3),can influence the dynamics of the spiral waves.1) Strong enough stimuli can change the spiral wave from a meandering to a rigidly rotating one.2) On the other hand,strong enough stimuli can suppress the spiral wave from the system.It provides the theoretical clue for controlling the spiral waves by stimulating the cell membrane.

A modified spatially extended Tang-Othmer Ca2 + model is used to study intracellular Ca2 + spiral waves numerically. It is found that, as a local stimulation, the local agonist-binding on the cell membrane, which enhances the local concentration of the messenger molecule inositol 1 , 4,5-trisphosphate (IP 3), can influence the dynamics of the spiral waves.1) Strong enough stimuli can change the spiral wave from a meandering to a rigidly rotating one.2) On the other hand, strong enough stimuli can suppress the spiral wave from the system. It provides the theoretical clue for controlling the spiral waves by stimulating the cell membrane.