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目的探讨胰岛素泵间歇强化治疗对青少年2型糖尿病患者的临床疗效析。方法将76例患者按就诊顺序随机分为间歇胰岛素泵治疗组(A)、胰岛素皮下注射治疗组(B)和口服药物组(C),A组予胰岛素泵持续皮下注射结合口服降糖药交替应用控制血糖,B组以传统方式皮下注射胰岛素,C组单纯口服瑞格列奈治疗,观察血糖达标时间、低血糖发生率,3组治疗完成后测患者空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、尿微量白蛋白排泄率(UAER)并进行比较。结果A组治疗后低血糖发生率、2hPG、TG均优于B组(p>0.05)、与C组比较则各项数据均有显著差异(p<0.01)。A组血糖达标时间与B组差异无显著性,但明显优于C组。结论间歇胰岛素泵强化治疗也能有效控制血糖,达到甚至优于常规使用胰岛素的效果,而且更安全能;能降低血脂及减少尿微量白蛋白的排泄,保护肾功能;而口服降糖药疗效及安全性均较差,且无肾脏保护作用。
Objective To investigate the clinical effect of insulin pump intermittent intensive treatment on adolescents with type 2 diabetes mellitus. Methods Seventy-six patients were randomly divided into intermittent insulin pump treatment group (A), insulin subcutaneous injection treatment group (B) and oral drug group (C) according to the order of treatment. Patients in group A received continuous insulin infusion and subcutaneous injection of oral hypoglycemic agents Application of control blood sugar, B group in the traditional way of subcutaneous insulin, C group was treated with oral repaglinide alone, the observed time of blood glucose, the incidence of hypoglycemia, the three groups after treatment, the fasting blood glucose (FPG), 2h postprandial blood glucose (2hPG), HbA1c, triglyceride (TG), urinary albumin excretion rate (UAER) were compared and compared. Results The incidence of hypoglycemia, 2hPG and TG in group A were significantly higher than those in group B (p> 0.05). There was significant difference between group A and group C (p <0.01). A group of blood glucose compliance time and B group no significant difference, but significantly better than C group. Conclusion Intermittent insulin pump can also be effective in controlling blood glucose control, to achieve or even better than the conventional effect of insulin, but also safer; can reduce blood lipids and reduce urinary albumin excretion and protection of renal function; and oral antidiabetic drug efficacy and Safety is poor, and no protection of the kidneys.