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目的:了解我院2009～2010年β-内酰胺类抗菌药不良反应发生情况,分析其影响因素,以促进临床合理用药。方法:收集我院2009～2010年上报告国家药品不良反应监测中心的282例β-内酰胺类抗菌药的药品不良反应(ADR)报告,分别从患者年龄、性别、给药途径、使用药物种类以及临床表现等方面进行统计分析。结果:ADR涉及β-内酰胺类抗菌药共33种,以头孢曲松居首位,其次为头孢呋辛和氨曲南;以静脉途径给药引发的ADR最多;282例ADR中,大于60岁患者构成比最高(28.72%);临床表现以皮肤及其附件损害最常见。结论:β-内酰胺类抗菌药发生ADR与年龄、给药途径等多种因素相关,应规范β-内酰胺类抗菌药的临床应用,减少ADR的发生。
Objective: To understand the incidence of adverse reactions of β-lactam antibiotics in our hospital from 2009 to 2010, analyze the influencing factors and promote the rational use of drugs. Methods: A total of 282 ADR cases of β-lactam antibiotics were collected from our national ADR surveillance center in our hospital from 2009 to 2010. The ADRs were collected from patients’ age, sex, route of administration, As well as clinical manifestations and other aspects of statistical analysis. RESULTS: There were 33 β-lactam antibiotics involved in the study, with ceftriaxone as the first place, followed by cefuroxime and aztreonam, ADR caused by intravenous route was the most, ADR was more than 282 years old Composition ratio (28.72%); the most common clinical manifestations of damage to the skin and its accessories. Conclusion: The ADR of β-lactam antibiotics is related to many factors such as age, route of administration and so on. The clinical application of β-lactam antibiotics should be standardized to reduce the occurrence of ADR.