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４０日龄Ｗｉｓｔａｒ雄性大鼠５Ｏ只，按体重随机分为对照（Ｃ）组和糖尿病Ｄ４０、Ｄ４５、Ｄ５０、Ｄ５５共５组。Ｃ组腹腔注射赋形剂，糖尿病组分别腹腔注射链脲菌素（ＳＴＺ）４０ｍｇ，４５ｍｇ，５０ｍｇ和５５ｍｇ／ｋｇ体重，观察２个月。结果表明，发病率依次为Ｄ４０＜Ｄ４５＜Ｄ５０＜Ｄ５５，Ｄ５５组为１００％；自然阴转率Ｄ４０＞Ｄ４５＞Ｄ５０＞Ｄ５５为０％；病死率Ｄ５５组最高，达３３％。观察期间５次测血糖水平和体重变化，结果表明，Ｄ５５组平均血糖＞２２．２ｍｍｏｌ／Ｌ，Ｄ５０组平均血糖维持在（１６．７～２２．２）ｍｍｏｌ／Ｌ之间，Ｄ４０、Ｄ４５组在较低值水平上波动；Ｄ４０、Ｄ４５、Ｄ５０、Ｄ５５组体重增长率均比Ｃ组显著低，Ｄ５５组最低。结论是：复制青春期糖尿病模型以ＳＴＺ５０或５５ｍｇ／ｋｇ体重腹腔注射为佳。
Forty male Wistar rats of 40 days old were randomly divided into control group (C) and diabetes D40, D45, D50 and D55 according to body weight. Rats in group C were intraperitoneally injected with streptozotocin (STZ) 40 mg, 45 mg, 50 mg and 55 mg / kg body weight respectively for 2 months. The results showed that the morbidity rates were D40 D45> D50> D55 and 33% in D55 group. The blood sugar level and body weight were measured 5 times during the observation period. The results showed that the mean blood glucose of D55 group was> 22.2mmol / L, the average blood glucose of D50 group was maintained between (16.7-22.2) mmol / L, D40, D45 group Fluctuated at a lower level. The body weight growth rate of D40, D45, D50 and D55 groups was significantly lower than that of C group and lowest in D55 group. The conclusion is: Copy adolescent diabetes model to STZ50 or 55mg / kg body weight intraperitoneal injection is better.