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近来盐酸多巴胺常用作新生儿的肌力收缩增强剂,而新生儿的重症监护病室中常设有蓝光治疗装置。鉴于盐酸多巴胺的氧化作用可受氧、热,重金属以及光的催化,氧化产物无治疗活性,本文对盐酸多巴胺溶液暴露在具有高辐射或光能的蓝光下的稳定性进行了研究。用50%葡萄糖注射液将盐酸多巴胺配制成1000μg/ml 溶液,光源来自4个F_(40B)蓝色灯泡组成的光治疗装置,光波长为400～500nm,辐射水平维持在5.1～6.6μW/cm~2,采用两种流速(2ml/h 及无流速),同时用荧光及暗光二种光源作对照。所有溶液在室温(25
Recently, dopamine hydrochloride is often used as a neonatal muscle contractile enhancer, and neonatal intensive care unit often equipped with blue light therapy device. Since the oxidation of dopamine hydrochloride can be catalyzed by oxygen, heat, heavy metals and light, and the oxidation products have no therapeutic activity, the stability of dopamine hydrochloride solution exposed to blue light with high radiation or light energy was studied in this paper. Dopamine hydrochloride was formulated into 1000μg / ml solution with 50% glucose injection from four F_ (40B) blue light bulbs. The wavelength of light was 400 ~ 500nm and the radiation level was maintained at 5.1 ~ 6.6μW / cm ~ 2, using two flow rates (2ml / h and no flow), while using fluorescent and dark light two light sources as a control. All solutions are at room temperature (25