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目的探讨被动吸烟健康青年人血管内皮舒张功能及血浆一氧化氮(NO)、血管紧张素Ⅱ(AⅡ)的水平变化。方法采用超声肱动脉内径测量法,观察被动吸烟、主动吸烟及正常对照者各30名血流介导的和硝酸甘油介导的肱动脉内径变化,同时测定各组血浆NO、AⅡ。结果三组肱动脉内径基础值及硝酸甘油介导的肱动脉舒张均无显著性差异(P>0．05),而血流介导的血管扩张被动吸烟组与正常对照组间存在显著差异(P<0．01),与吸烟组无显著性差异(P>0．05)。NO在主、被动吸烟组减低,AⅡ在主、被动吸烟组升高。结论被动吸烟导致健康青年人血管内皮舒张功能损伤可能与血浆NO减少、AⅡ增加有关。
Objective To investigate the changes of vascular endothelial relaxation and plasma levels of nitric oxide (NO) and angiotensin Ⅱ (AⅡ) in healthy smokers with passive smoking. Methods Ultrasound brachial artery diameter measurement was used to observe the change of brachial artery diameter mediated by 30 blood flow and nitroglycerin in passive smoking, active smoking and normal control, and plasma NO and AⅡ in each group were also measured. Results There was no significant difference in the basic values of brachial artery diameter and nitroglycerin-mediated brachial artery diastolic in the three groups (P> 0.05), but there was a significant difference between the blood flow-mediated vasodilatation passive smoking group and the normal control group P <0.01), no significant difference with smoking group (P> 0.05). NO in the main, passive smoking group reduced, A Ⅱ in the main, passive smoking group increased. Conclusion Passive smoking may lead to impairment of vascular endothelial function in healthy young people, which may be related to the decrease of NO and the increase of AⅡ in plasma.