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目的探讨动脉灌注化疗联合后程加速超分割三维适形放疗晚期食管癌的临床应用。方法90例晚期食管癌患者随机分为单纯后程加速超分割三维适形放疗组(单放组)和动脉灌注化疗联合后程加速超分割三维适形放疗组(综合组),并在治疗后进行随访,观察临床及放射学改善情况,评价治疗效果。结果治疗后大部分患者临床指标及X线片表现明显改善,综合组X线Ⅰ级片率明显高于单放组。综合组1,2,3年生存率分别为68.9%、44.4%和35.6%,单放组1,2,3年生存率分别为46.7%、24.4%和15.6%,两组间生存率差异有显著性(P<0.05)。两组毒副作用相似,差异无显著性。结论动脉灌注化疗联合后程加速超分割三维适形放疗是治疗晚期食管癌的一种安全、可靠、疗效满意的治疗方法。
Objective To investigate the clinical application of intra-arterial infusion chemotherapy and late-course accelerated hyperfractionated three-dimensional conformal radiotherapy for advanced esophageal cancer. Methods Ninety patients with advanced esophageal cancer were randomly divided into three groups: single course accelerated hyperfractionated three-dimensional conformal radiotherapy (group A) and arterial infusion chemotherapy combined with one-way accelerated fractionated three-dimensional conformal radiotherapy (group A) Follow-up, observation of clinical and radiological improvement, evaluation of the treatment effect. Results The clinical manifestations and X-ray findings of most patients after the treatment were significantly improved. The X-ray I slice rate of the comprehensive group was significantly higher than that of the radiotherapy alone group. The 1, 2, 3-year survival rates of the integrated group were 68.9%, 44.4% and 35.6% respectively, and the 1-, 2- and 3-year survival rates were 46.7%, 24.4% and 15.6% Significance (P <0.05). The two groups of similar side effects, no significant difference. Conclusion Arterial infusion chemotherapy combined with posterior accelerated three-dimensional conformal radiotherapy is a safe, reliable and effective treatment for advanced esophageal cancer.