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骨形态发生蛋白（ｂｏｎｅ ｍｏｒｐｈｏｇｅｎｅｔｉｃ ｐｒｏｔｅｉｎ，ＢＭＰ）是由Ｕｒｉｓｔ［１］在１９６５年对脱钙骨基质的成骨研究中发现的。他们将脱钙骨基质移植于动物的皮下和肌肉内，可诱导软骨化骨，随后从骨中分离出了一种小分子的糖蛋白，这种糖蛋白可诱导
Bone morphogenetic protein (BMP) was discovered by Urist [1] in the osteogenesis of decalcified bone matrix in 1965. They transplanted the decalcified bone matrix into the skin and muscle of animals, which induced the osteochondral bone, and then isolated a small molecule of glycoprotein from the bone, which glycoprotein was induced