论文部分内容阅读
目的 :用病例对照研究探讨肝炎肝硬化患者发生多重耐药菌感染的危险因素。方法 :选择发生多重耐药菌感染的肝炎肝硬变患者 18例作为病例组 ,发生敏感菌感染的肝炎肝硬变患者 91例作为对照组 ,进行流行病学调查。结果 :单因素分析发现院内感染、插管、血清总胆红素、抗生素应用时间为肝炎肝硬变患者发生多重耐药菌感染的可能危险因素。Logistic回归分析表明只有院内感染、抗生素应用时间与发生多重耐药菌感染有关。结论 :控制院内感染、合理应用抗生素可以减少肝炎肝硬变患者发生多重耐药菌感染的风险。
Objective: To explore the risk factors of multiple drug-resistant bacterial infections in patients with liver cirrhosis by case-control study. Methods: Eighteen patients with hepatitis cirrhosis who were infected with multiple drug-resistant bacteria were selected as the case group. Ninety-one patients with hepatitis-B cirrhosis who were susceptible to bacterial infection were selected as the control group for epidemiological investigation. Results: Univariate analysis found that nosocomial infections, intubation, serum total bilirubin and antibiotics were the possible risk factors for multiple drug-resistant bacterial infections in patients with hepatitis cirrhosis. Logistic regression analysis showed that only nosocomial infections, antibiotic application time and the occurrence of multiple drug-resistant bacterial infection. Conclusion: Control of nosocomial infections and rational use of antibiotics can reduce the risk of multiple drug-resistant bacterial infections in patients with hepatitis cirrhosis.