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目的 探讨PSA在前列腺癌临床诊疗中的应用价值。方法 采用ELISA法测定 3 3例健康者、3 6例良性前列腺增生及 3 3例前列腺癌治疗前后T PSA和F PSA并动态观察 2 0例放疗后T PSA水平变化。结果 前列腺癌T PSA和F PSA、F/T均显著高于良性前列腺增生 (P <0 .0 1) ;前列腺癌治疗后T PSA和F PSA显著下降 (P <0 .0 1) ,而F/T无明显改变 (P >0 .0 5 ) ;前列腺癌放疗后病情稳定T PSA下降 ,病情进展则T PSA升高。结论 动态测定前列腺癌患者治疗前后PSA水平变化 ,可判断近期疗效 ,监测病情变化。
Objective To investigate the value of PSA in clinical diagnosis and treatment of prostate cancer. Methods The T PSA and F PSA in 33 healthy controls, 36 benign prostatic hyperplasia (BPH) patients and 33 prostate cancer patients before and after treatment were measured by ELISA. The changes of T PSA level after 20 radiosurgery were observed. Results The T PSA, F PSA and F / T of prostate cancer were significantly higher than those of benign prostatic hyperplasia (P <0.01). The levels of T PSA and F PSA decreased significantly after prostate cancer treatment (P <0.01) / T had no significant change (P> 0.05); Prostate cancer stabilized after treatment of T PSA decreased, the progress of the disease is T PSA increased. Conclusions Dynamic determination of PSA levels in patients with prostate cancer before and after treatment can determine the short-term efficacy and monitor the changes of the disease.