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目的：以肝穿病理组织学研究中药复方８６１对慢性乙型肝炎及早期肝硬化的疗效。方法：中药８６１治疗慢性乙型肝炎及肝炎肝硬化１２例，另设对照组１０例，治疗前及治疗半年后行肝穿病理组织学检查。结果：肝炎症计分由治疗前１８．２５±７．４下降至治疗后８．５±２．７（Ｐ值＜０．００１），纤维化计分由１０±９．９２下降至２．５８±２．０７（Ｐ值＜０．０１）。对照组治疗后则无改变。平滑肌α－ａｃｔｉｎ染色见治疗前肝组织炎症区域中有较多肌成纤维细胞，治疗后显著减少。治疗前后血清乙肝指标无明显变化。结论：中药复方８６１治疗慢性肝炎肝纤维化半年，能明显减轻肝纤维化程度。肝组织炎症亦同步减退。
Objective: To observe the curative effect of Chinese herbal compound 861 on chronic hepatitis B and early cirrhosis by histopathology. Methods: 861 Chinese medicine treatment of chronic hepatitis B and hepatitis cirrhosis in 12 cases, another set of 10 cases of control group, before treatment and after six months of liver biopsy histological examination. Results: The score of hepatitis decreased from 18.25 ± 7.4 before treatment to 8.5 ± 2.7 after treatment (P <0.001), and the fibrosis score decreased from 10 ± 9.92 to 2. 58 ± 2.07 (P <0.01). The control group did not change after treatment. Smooth muscle α-actin staining showed more myofibroblasts in the inflammatory area of the liver before treatment, with a significant reduction after treatment. Serum hepatitis B before and after treatment no significant change. Conclusion: Chinese herbal compound 861 can treat liver fibrosis of chronic hepatitis for half a year, and can significantly reduce the degree of liver fibrosis. Liver inflammation also decreased synchronously.