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目的 探讨阻塞性睡眠呼吸暂停低通气综合征 (OSAHS)患者呼吸阻抗的特征和临床意义。方法 测定并分析 5 2例OSAHS患者、13例COPD患者、17例健康人多导睡眠图 (PSG)、脉冲振荡法 (IOS)指标。结果 ⑴OSAHS组总呼吸阻抗、中心气道阻抗、R2 0明显高于正常对照组 (P <0 0 5 ) ;响应频率、外周气道阻抗、R5、R5 -2 0、X5、X3 5与正常对照组无显著差异 (P >0 0 5 )。⑵OSAHS组响应频率、总呼吸阻抗、外周气道阻抗、R5、R5 -2 0明显低于COPD组 (P <0 0 1)。⑶OSAHS患者SaO2 与总呼吸阻抗、中心气道阻抗、R5、R2 0呈负相关 (P <0 0 1) ,AHI与总呼吸阻抗、中心气道阻抗、R5、R2 0呈正相关 (P <0 0 1)。结论 OSAHS患者IOS表现为上气道阻力升高 ,并与病情程度相关。
Objective To investigate the characteristics and clinical significance of respiratory resistance in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods Fifty-two patients with OSAHS, 13 patients with COPD, and 17 healthy subjects with polysomnography (PSG) and pulse oscillatometry (IOS) were measured and analyzed. Results (1) The total respiration impedance and central airway resistance in OSAHS group were significantly higher than those in normal control group (P <0 05). The response frequency, peripheral airway resistance, R5, R5 -2 0, X5 and X3 5 were significantly lower than those in normal control group There was no significant difference between the two groups (P> 0.05). ⑵OSAHS group response frequency, total respiration impedance, peripheral airway resistance, R5, R5 -2 0 was significantly lower than the COPD group (P <0.01). (3) There was a negative correlation between SaO2 and total respiration, central airway resistance, R5 and R2 0 in OSAHS patients (P <0.01), AHI was positively correlated with total respiration, central airway resistance, R5 and R2 0 1). Conclusion IOS in patients with OSAHS manifested as an increase in upper airway resistance, which was related to the severity of the illness.