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目的研究基层医院应用喹诺酮类抗菌药物的效果及安全性。方法选择2014年5月至2016年5月接诊的60例应用喹诺酮类药物进行治疗的患者作为治疗组展开本次研究。另外选取适应症相同但应用其他药物进行治疗的患者60例作为对照组进行研究。分析两组患者用药的疗效,及不良反应状况。结果治疗组的总有效率为91.67%,对照组总有效率为66.67%,两组比较有统计学意义(χ2=11.3684,P=0.0007)。治疗组患者的消化系统、神经系统的不良反应发生率明显低于对照组,总不良反应发生率(16.67%)明显低于对照组(38.33%),两组比较有统计学意义(χ2=7.0637,P=0.0079)。观察组不良反应的患者>60岁、静脉给药及不良反应出现时间≥6d所占比例(70.00%、90.00%、50.00%)明显高于对照组(30.43%、52.17%、13.04%),两组比较有显著性差异(P<0.05)。结论喹诺酮类抗菌药物在基层医院抗感染治疗过程中,疗效显著,不良反应发生率较低,安全性良好,值得在临床中广泛推广应用。
Objective To study the effect and safety of quinolone antibacterials in primary hospitals. Methods A total of 60 patients treated with quinolones from May 2014 to May 2016 were selected as the treatment group. In addition to select the same indications but the application of other drugs for treatment of 60 patients as a control group to study. Analysis of two groups of patients with the efficacy of medication, and adverse reactions. Results The total effective rate was 91.67% in the treatment group and 66.67% in the control group, with statistical significance (χ2 = 11.3684, P = 0.0007). The incidence of adverse reactions in the digestive system and nervous system in the treatment group was significantly lower than that in the control group (16.67% vs 38.33%, χ2 = 7.0637 , P = 0.0079). The adverse reactions of observation group> 60 years old, the proportion of intravenous administration and adverse reaction occurred more than 6 days (70.00%, 90.00%, 50.00%) was significantly higher than that of the control group (30.43%, 52.17%, 13.04% Group had significant difference (P <0.05). Conclusions Quinolone antibacterials are effective in anti-infective therapy in primary hospitals, with low incidence of adverse reactions and good safety. It is worth to be widely applied in clinical practice.