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目的 :比较不同剂量的罗库溴铵在全麻诱导气管插管时的起效时间、恢复时间、肌松程度及其解迷走神经作用.方法 :全麻下手术 60例 ,依罗库溴铵剂量分 3组 ,每组 2 0例 ,依次注入咪唑安定 0 2mg/kg ,异丙酚 2 0mg/kg和芬太尼 5μg/kg ,后按组注入不同剂量的罗库溴铵行全麻诱导气管插管 ,观察起效时间 ,恢复时间 ,同时观察心率、血压、心电图等心血管反应作为解迷走神经反应的指标.结果 :三组插管条件均为优等 ,注药前后无明显的心血管反应 ,起效时间 0 6mg/kg组明显长于0 9mg/kg组 ,恢复时间后者明显长于前者 ,50mg/例起效时间和恢复时间均介于前 2组间.结论 :罗库溴铵随剂量增加起效时间缩短而恢复时间延长 ,当剂量达 0 9mg/kg时其解迷走神经作用仍不明显 ,成人一律选用 50mg/例作气管插管简便可行 ,可供临床选用“,”Objective: To compare the onset time, duration, relaxant depth and devagus nerve effect of rocuronium in three different doses undergoing balanced anesthesia. Methods: 60 cases divided randomly into 3 groups(20cases/group) were anesthetized with Midazolam 0.2mg/kg, Propofol 2.0mg/kg, Fentanyl 5μg/kg and rocuronium 0.6mg/kg (Ⅰ)0.9mg/kg(Ⅱ)50mg(Ⅲ)respectively. Tracheal intubations were performed by the TOF_GUARD monitoring.The onset time and the duration time were observed,also BP, P, ECG (devagus index) simultanelously.Results: The relaxant depth was excellent in all cases.No markedly cardiovascular effect was found compared with preinjection. The onset time is 110±12 9sec (Ⅰ)73±16 5sec,(Ⅱ)82±25sec, (Ⅲ)respectively and the druation time is 45±12 2min ,(Ⅰ)70±20.5min,(Ⅱ)58±18.6min,(Ⅲ)respectively. Conclusion: Rocuronium is a short-moderated non-depolarizing neuromuscular blocking. The onset is shortened and the duration is delayed when the dose is increased during 2-3ED95. No devagus nerve effec is found so much as the dose reaches to 0.9mg/kg. So 50mg Rocuronium (equal to 0 8±1 2mg/kg) is available in these cases provided with convenience practically.