论文部分内容阅读
目的:观察解郁一号方联合盐酸帕罗西汀治疗帕金森病合并抑郁症状的临床疗效。方法:将68例帕金森病合并抑郁症状的患者纳入研究,随机分为实验组和对照组各34例,实验组给予盐酸帕罗西汀联合解郁一号方治疗,对照组给予盐酸帕罗西汀治疗,采用汉密尔顿抑郁量表(HAMD)评价治疗效果。结果:2组治疗后HAMD评分均较治疗前下降,与治疗前相比,实验组在治疗1周见效,差异有统计学意义(P<0.05),对照组在治疗1周,差异无统计学意义(P>0.05),2、4、6、8周末,差异有统计学意义(P<0.05);第2、4、6、8周末,实验组HAMD评分均低于同期对照组,差异有统计学意义(P<0.05)。结论:解郁一号方联合盐酸帕罗西汀治疗帕金森病合并抑郁症状较单用盐酸帕罗西汀起效快,效果好。
Objective: To observe the clinical efficacy of Jieyu Prescription combined with paroxetine in the treatment of Parkinson’s disease with depressive symptoms. Methods: Sixty-eight patients with Parkinson’s disease complicated with depressive symptoms were enrolled and randomly divided into experimental group and control group with 34 cases each. The experimental group was treated with Paroxetine Hydrochloride combined with Jieyu Decoction and the control group with Paroxetine Hydrochloride. The Hamilton Depression Rating Scale (HAMD) was used to evaluate the therapeutic effect. Results: The HAMD scores of two groups decreased after treatment compared with those before treatment. The experimental group was effective in one week after treatment, the difference was statistically significant (P <0.05), while the control group had no significant difference in one week (P> 0.05). There was a significant difference between the two groups at the end of 2,4,6,8 (P <0.05). At the end of the 2nd, 4th, 6th and 8th week, the HAMD scores of the experimental group were lower than those of the control group Statistical significance (P <0.05). Conclusion: The combination of Jieyu Decoction and paroxetine hydrochloride in the treatment of Parkinson’s disease with depressive symptoms is faster and more effective than single paroxetine hydrochloride.