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过氧化物酶体增殖物激活受体(peroxisome proliferator activated receptor,PPAR)是一类由配体激活的核转录因子,属于核内受体超家族成员。PPAR存在天然配体和人工合成配体2类。天然配体主要来源于食物和机体的代谢产物,人工合成配体主要是贝特类降脂药物和噻唑烷二酮类降糖药物。目前发现,有些中药成分也可以作为PPAR的配体。文中对可作用于PPAR的中药配体研究作一综述。
Peroxisome proliferator activated receptor (PPAR) is a family of ligand-activated nuclear transcription factors that belong to the nuclear receptor superfamily. PPAR exists in natural ligands and synthetic ligands 2 categories. Natural ligands are mainly derived from food and the body’s metabolites, synthetic ligands are mainly fibrates lipid-lowering drugs and thiazolidinediones hypoglycemic drugs. It is found that some traditional Chinese medicine ingredients can also act as PPAR ligands. This review summarizes the studies on ligands of traditional Chinese medicines that can act on PPAR.