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给麻醉家兔静脉注射仙灵脾相当于生药4克/公斤甲醇提取物,血压急剧下降到正常的80%,旋又逐渐回升约在2小时后回到正常。反复给药无急性耐受性。正常大鼠一次灌胃10克/公斤,血压下降到20—30%,维持约4小时。肾型高血压大鼠按同样剂量灌胃给药每日一次,血压逐渐下降,于第五日降至最低水平,约为正常80%,停药后血压逐渐回升,到第五日达到给药前水平,但仍明显低于对照动物。仙灵脾能减弱压迫颈动脉的加压反应,但对带神经的离体兔耳血管灌流没有影响。反之,它却能明显增加离体兔耳及兔肾血管灌注液的流出量。仙灵脾没有加强乙酰胆碱和对抗肾上腺素对于血压的作用,也不抑制在位兔心的收缩力。仙灵脾的降压作用可能主要是由于直接抑制周围血管所致。
Intravenous injection of an immortalized spleen to anesthetized rabbits was equivalent to a 4 g/kg methanol extract of crude drug. The blood pressure dropped sharply to 80% of normal, and the rotation gradually returned to normal about 2 hours later. Repeated administration is not acutely tolerable. Normal rats were given 10 g/kg gavage once and blood pressure dropped to 20-30% for about 4 hours. Renal hypertensive rats were given intragastrically once a day at the same dose and their blood pressure gradually decreased to the lowest level on the fifth day, which was approximately 80% of the normal level. Blood pressure gradually increased after discontinuation and reached the fifth day after administration. Pre-level but still significantly lower than control animals. Epimedium can weaken the pressurization response of the carotid artery, but has no effect on the vascular perfusion of rabbit ears with nerves. On the contrary, it can significantly increase the outflow of perfused fluid from isolated rabbit ears and rabbit kidney vessels. Epimedium did not enhance the effects of acetylcholine and adrenaline on blood pressure, nor did it inhibit the contractility of rabbit hearts. The antihypertensive effect of epimedium may be mainly due to direct suppression of peripheral blood vessels.