论文部分内容阅读
目的探讨腺泡状软组织肉瘤的临床治疗和预后。方法对１９７３～１９９６年间收治的２２例腺泡状软组织肉瘤患者的临床资料进行回顾性分析。结果２２例均接受手术治疗，其中１７例行肿瘤局部切除，５例行扩大切除。７例病理误诊为其他软组织肿瘤（占３２％）。９例术后进行了预防性辅助放疗和（或）化疗。对２１例患者随访４个月至９年。６例患者术后复发（占２８％），１３例出现肺转移（占６２％），５例在随访８个月至４年５个月时死亡（占２４％），６例患者生存５年以上。全组经ＫａｐｌａｎＭｅｉｒｅ生存率计算其３年、４年、５年生存率分别为８３％、７５％及６６％。结论腺泡状软组织肉瘤多需病理学诊断，肿瘤局部切除是复发和转移最重要的因素，术后预防性辅助治疗对局部复发和转移没有明显的控制作用，对出现肺转移的患者采取多程标准化疗方案进行治疗，临床效果尚满意
Objective To investigate the clinical treatment and prognosis of alveolar soft tissue sarcoma. Methods The clinical data of 22 patients with alveolar soft tissue sarcoma treated from 1973 to 1996 were retrospectively analyzed. Results Twenty-two cases received surgical treatment. Among them, 17 cases underwent local tumor resection and 5 cases underwent extended resection. 7 cases were misdiagnosed as other soft tissue tumors (32%). Nine patients received postoperative adjuvant radiotherapy and/or chemotherapy. Twenty-one patients were followed up for 4 months to 9 years. Six patients had recurrence (28%), 13 had pulmonary metastases (62%), 5 patients died at follow-up from 8 months to 4 years and 5 months (24%), and 6 patients survived 5 years. the above. The three-year, four-year, and five-year survival rates of the whole group calculated by the Kaplan-Meire survival rate were 83%, 75%, and 66%, respectively. Conclusion Alveolar soft tissue sarcoma needs more pathological diagnosis. Local resection of tumor is the most important factor for recurrence and metastasis. Prophylactic adjuvant therapy has no obvious effect on local recurrence and metastasis, and it takes multiple courses for patients with pulmonary metastasis. Standard chemotherapy regimen for treatment, clinical results are still satisfactory