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生殖器疱疹是目前世界上以及我国沿海地区常见性病之一,而且发病率有逐渐增高趋势。生殖器疱疹病毒(HSV)不但引起原发感染,还会产生潜伏和复发感染。无论是有临床表现的生殖器疱疹或是无症状的潜伏感染,都可以传染给性伴侣,妊娠的妇女还可垂直传染给胎儿。虽然目前的抗病毒药阿昔洛韦、泛昔洛韦以及缬昔洛韦的应用对缩短有症状生殖器疱疹病程和重症患者的治疗取得了明显效果,但是不能有效预防疱疹病毒感染以及控制潜伏、复发生殖器疱疹。因此疱疹病毒疫苗的研究为预防和控制复发生殖器疱疹带来了曙光。
Genital herpes is one of the most common venereal diseases in the world and in the coastal areas of our country, and the incidence is gradually increasing. Genital herpes virus (HSV) not only causes primary infection but also latent and recurrent infections. Whether it is a clinical manifestation of genital herpes or asymptomatic latent infection, can be transmitted to sexual partners, pregnant women can also be transmitted vertically to the fetus. Although the current antiviral drugs acyclovir, famciclovir, and valciclovir have shown significant effects in shortening the duration of symptomatic genital herpes and in the treatment of critically ill patients, they are not effective in preventing herpes virus infections and in controlling latent, recurrent genital herpes . Therefore, the study of herpes virus vaccine for the prevention and control of recurrent genital herpes brought the dawn.