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目的:探讨联合应用葡萄糖-6-磷酸脱氢酶(G6PD)四氮唑蓝(NBT)纸片定性法与G6PD/6PGD比值定量法在大样本筛查中的可行性。方法:用NBT纸片定性法对501例贵州省江口县土家族、525例从江县侗族、586例荔波县瑶族共1612例成人进行定性初筛,再用G6PD/6PGD比值法对初筛阳性样本定量复查。结果:NBT纸片定性法共初筛出G6PD缺陷患者129例,G6PD/G6PD比值法确诊G6PD缺陷123例,2种方法的符合率高达95.35%。结论:对大样本G6PD缺陷症的筛查,先用NBT纸片定性法进行初筛,再用G6PD/6PGD比值法复查确诊,2法联合应用可以提高G6PD缺陷症检出率和节约大量经费和时间。
OBJECTIVE: To investigate the feasibility of combining G6PD tetrazolium blue (NBT) paper qualitative method with G6PD / 6PGD ratio quantitative method in large sample screening. Methods: A total of 1612 adults, 501 from Tujia, Jiangkou County, Guizhou Province, 525 from Dongjiang County and 586 from Libo County, were qualitatively screened by NBT disc qualitative method and then screened by G6PD / 6PGD method Positive sample quantitative review. Results: 129 cases of G6PD deficiency were initially screened by NBT disc qualitative method. 123 cases of G6PD deficiency were diagnosed by G6PD / G6PD ratio method. The coincidence rate of two methods was 95.35%. Conclusion: The screening of large samples of G6PD deficiency is first screening by NBT disc qualitative method and then by G6PD / 6PGD ratio method. The combination of 2 methods can improve the detection rate of G6PD deficiency and save a large amount of funds time.