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目的:观察唑来磷酸治疗恶性肿瘤骨转移疼痛的临床疗效。方法:将40例恶性肿瘤骨转移伴疼痛患者随机分为治疗组(24例)和对照组(16例),治疗组给予唑来磷酸4mg静脉滴注15分钟,每4周重复1次,对照组给予帕米膦酸二钠90mg静脉滴注4小时以上,治疗3次后观察疼痛缓解情况及药物不良反应。结果:治疗组总有效率为79.17%(19/24),对照组总有效率68.75%(11/16),2组比较差异无明显统计学意义(P>0.05);治疗组平均起效时间3.9天,对照组平均起效时间8.1天,2组比较差异有统计学意义(P<0.05),不良反应发生率均较低。结论:唑来磷酸治疗骨转移癌疼痛起效迅速,疗效确切,无严重不良反应发生。
Objective: To observe the clinical efficacy of zoledronic acid in the treatment of malignant bone metastases. Methods: Forty patients with malignant bone metastasis and pain were randomly divided into treatment group (24 cases) and control group (16 cases). Patients in the treatment group were treated with zoledronic acid 4 mg intravenously for 15 minutes and repeated every 4 weeks. Group given pamidronate 90mg intravenous infusion of more than 4 hours, 3 times after treatment to observe the pain relief and adverse drug reactions. Results: The total effective rate was 79.17% (19/24) in the treatment group and 68.75% (11/16) in the control group, with no significant difference between the two groups (P> 0.05). The mean effective time 3.9 days, the average onset time of 8.1 days in the control group, the difference between the two groups was statistically significant (P <0.05), the incidence of adverse reactions are low. Conclusion: Zoledronic acid treatment of bone metastases pain rapid onset, the exact effect, no serious adverse reactions.