Molecular Cloning, Characterization and Expression Analysis of Woodchuck Retinoic Acid-Inducible Gen

• 作 者: 严琦 刘钦 李蒙蒙 李芳慧 朱彬 Jun-zhong WAN
• 机 构: DepartmentoflnfectiousDiseases,InstituteofVirology
• 出 处: 华中科技大学学报：医学英德文版
• 发表日期: 2016年3期
• 关键词: 诱导基因 土拨鼠 视黄酸 分子克隆 表达分析 乙型肝炎病毒 小干扰RNA caspase retinoic acid-inducible gene I wood
• 基金项目: supported by grants from the National Science and Technology Major Project for Infectious Diseases of China（No.2012ZX10004503）, the National Natural Science Foundation of China（No.81101248,No.81261120

Cytosolic retinoic acid-inducible gene I(RIG-I) is an important innate immune RNA sensor and can induce antiviral cytokines, e.g., interferon-β(IFN-β). Innate immune response to hepatitis B virus(HBV) plays a pivotal role in viral clearance and persistenc