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目的了解中山大学孙逸仙纪念医院门诊阿司匹林超说明书用药现状,为制订超说明书用药政策提供基线数据。方法采用分层随机抽样的方法,收集2013年门诊阿司匹林的处方数据,采用卡方检验比较阿司匹林超说明书用药不同类型间发生率,采用logistic回归模型分析阿司匹林各类超说明书用药发生的影响因素。结果共抽取门急诊阿司匹林处方5 023张,超说明书用药率达17.7%。超说明书超适应证使用高达94.38%,超适应证前3分别为:复发性流产、不孕症和系统性红斑狼疮。年龄、性别、药品规格、处方开具科室均是超说明书用药风险因素。结论中山大学孙逸仙纪念医院2013年门诊阿司匹林超说明书用药情况普遍,以妇产科和生殖中心女性生殖超说明书用药现象最显著,提示仍需促进阿司匹林在生殖方面的临床试验以提供更多的用药证据,保障阿司匹林的用药安全和规避相关医疗风险。
Objective To understand the status quo of aspirin super instruction manual of Sun Yat-sen Memorial Hospital of Sun Yat-sen University and to provide baseline data for formulating super instruction manual medication policy. Methods The stratified random sampling method was used to collect the prescription data of outpatient aspirin in 2013. The incidence of aspirin hypersensitivity was compared by chi-square test. Logistic regression model was used to analyze the influencing factors of aspirin use. Results A total of 502 outpatient and emergency aspirin prescriptions were drawn, and the rate of super instruction was 17.7%. Ultra-description of the use of ultra-indications up to 94.38%, the first three were: recurrent miscarriage, infertility and systemic lupus erythematosus. Age, sex, drug specifications, prescriptions issued department are super manual drug risk factors. Conclusion Sun Yat-sen Memorial Hospital, Sun Yat-sen Memorial Hospital outpatient aspirin in 2013 super-instructions for medication prevalence to obstetrics and gynecology and reproductive centers female reproductive hype description of the most significant drug use, suggesting that still need to promote aspirin in the reproductive clinical trials to provide more evidence of medication , To ensure the safety of aspirin medication and avoid related medical risks.