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人体和小鼠试验表明,尽管抗体在防御百日咳杆菌定居于呼吸道和毒素介导疾病方面具有重要作用,但是,T细胞Th1亚群介导的免疫应答则是从体内完全清除百日咳杆菌所必需的。
Human and mouse trials have shown that while the antibodies play an important role in preventing Bordetella pertussis colonizing respiratory and toxin-mediated diseases, the immune response mediated by the Th1 subset of T cells is required for the complete clearance of Bordetella pertussis in vivo.