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骨髓纤维化(以下简称骨纤)的病因不明。有认为是一种类似白血病的疾病,亦有认为由其他疾病引起,本文发现患者在外周血液白细胞中有免疫复合物,故提出有自身免疫引起的可能性。本文12例(男8,女4)患者,症状不一,全部具有显著的脾肿大,有的尚有贫血、胁痛,出现异形红细胞、不成熟的红白细胞、血小板增多或减少。全部病例均经骨髓活检证实,每一例均见有网状蛋白或胶原数量的显著增加。多数患者外周血液检查,T淋巴细胞的百分率轻度下降,B淋巴细胞正常。
The cause of myelofibrosis (hereinafter referred to as bone fiber) is unknown. Have considered that a leukemia-like disease, also considered to be caused by other diseases, the paper found that patients with immune complexes in peripheral blood leukocytes, it is proposed the possibility of autoimmune. In this paper, 12 cases (male 8, female 4) patients with different symptoms, all with significant splenomegaly, and some anemia, hypochondriac pain, there are irregular red blood cells, immature white blood cells, thrombocytosis increased or decreased. All cases were confirmed by bone marrow biopsy, each case showed a significant increase in the number of reticular protein or collagen. The majority of patients with peripheral blood tests, the percentage of T lymphocytes decreased slightly, B lymphocytes normal.