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肿瘤发展过程中常出现免疫抑制。免疫抑制表现有体液免疫抑制、细胞免疫抑制或两种抑制同时存在。一般而言,实体瘤宿主通常是体液免疫反应正常、而T 细胞免疫反应抑制;病毒诱发的白血病两种免疫均被抑制;浆细胞瘤出现体液免疫抑制,而T 细胞功能正常。免疫抑制时,免疫监视机制遭到破坏,常导致肿瘤进行性生长及致死性转移。导致免疫抑制的因素有两种:一种是体液因素;另一种是细胞因素。细胞因素有T 抑制细胞、B 抑制细胞、抑制性巨噬细胞、Null 细胞(裸细胞)、多核白细胞等。这些抑制细胞作用的对象是免疫活性细
Immunosuppression often occurs during tumor development. Immunosuppressive manifestations are humoral immunosuppression, cellular immunosuppression, or both. In general, solid tumor hosts are usually normal humoral immune responses, whereas T-cell immune responses are suppressed; both virus-induced leukemias are suppressed; plasmacytomas exhibit humoral immunosuppression and T-cell functions normally. Immunosuppression, immune surveillance mechanisms have been destroyed, often leading to tumor growth and lethal metastasis. There are two factors that lead to immunosuppression: one is the fluid factor and the other is the cytokine. Cytokines are T suppressor cells, B suppressor cells, inhibitory macrophages, Null cells (nude cells), and multicellular leukocytes. These cytostatic agents are immunocompetent